Stop the Clock: The Optimal Anti-Aging Strategy by P. D. Mangan

Author:P. D. Mangan [Mangan, P. D.]
Language: eng
Format: epub, mobi
Publisher: Phalanx Press
Published: 2015-06-20T07:00:00+00:00

Aspirin has two different effects.

The first is that it lowers the risk of cardiovascular events like heart attack and stroke by reducing the chance of blood clots, which are the precipitating factors for these cardiovascular diseases. It does this by reducing the ability of blood platelets to stick together and to other surfaces. This effect is also the same one that may cause bleeding.

Aspirin's second effect is that it lowers inflammation by inhibiting certain enzymes and activating the energy sensor AMPK; this is the source of its anti-cancer and anti-aging effects. Recall that one of the hallmarks of aging is greater levels of inflammation, so a drug like aspirin that reduces inflammation can be of benefit for life extension. The tendency of aspirin to promote internal bleeding is certainly a downside, and some people will be more likely than others to manifest this risk. But the reduction in cancer risk may be even more important than the reduction in cardiovascular risk. The medical consensus currently recommends aspirin only for those who have had a previous heart attack or are otherwise at high risk for one, but as noted that consensus may be changing. For those of us who are trying to fight aging, aspirin poses a conundrum: any doctor that you might consult about taking low-dose aspirin will likely recommend against it, assuming that you have low cardiovascular risk. I'm not here to tell you otherwise, but you should be aware of aspirin and what it can do.

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